Langerhans cell histiocytosis and choledocholithiasis: a causal relationship or coincidence?

Address correspondence to: Dr. Arunkumar Krishnan, C-137, Karthikeyan salai, Periyar Nagar, Perambur, Chennai-600083, Tamilnadu, India; E-mail: [email protected] Langerhans cell histiocytosis (LCH), previously known as histiocytosis X, encompasses a diverse group of proliferative disorders characterized by infiltration and accumulation of histiocytes and other immune effector cells within various tissues.1 Clinical manifestations of LCH are varied and depend on the sites and extent of involvement; LCH can range from solitary disease of the bone to severe multivisceral involvement including the lungs, bone, liver, spleen, lymph nodes, hypothalamus, pituitary gland, and gastrointestinal tract. LCH typically occurs in children and adolescents, but it can develop in all age groups, and it has a male predominance.2 Manifestations of LCH vary depending on whether the patient has single-system or multisystem involvement, but hepatobiliary disease due to LCH is uncommon. This case reports LCH in a male child with neurologic symptoms (diabetes insipidus) and obstructive jaundice.